| 초록 |
In many tissue engineering fields, porous biodegradable polymer scaffolds with an interconnected open pore structure have been actively studied in clinical applications including plastic and reconstruction surgery with tissue-engineered artifical cartilage. Accordingly, such scaffolds must have some properties such as good biocompatibility, suitable biodegradability, and the ability to interact specifically with appropriate cells. These materials have insfficient initial cell binding sites and limited ability to cell adhesion for in vitro and in vivo tissue cultures because of their hydrophobic characteristics. Various efforts are now being attempted to overcome this problems. In this study, the biodegradable non-porous poly(L-lactic acid) (PLLA) films with hydrophobic surfaces were modified for hydrophilic ones by using plasma glow discharge treatment and some hydrophilic monomers such as acrylic acid (AA), 2-hydroxyethyl methacrylate (HEMA), and glycidyl methacrylate (GMA) for grafting of peptide ligands. The surface properties and cell adhesion on hydrophilic surface-modified non-porous PLLA films were compared with unmodified one. |
