| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 | 27권 1호, p.277 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation and Characterization of Antibiotic-loaded Collagen Film using SIS Powder for Wound Healing |
| 초록 | Collagen films prepared by treating collagen gel solutions with different concentrations of glutaraldehyde were evaluated as a biodegradable and biocompatible drug carrier for wound healing agent in this study. Collagen gel from SIS powder due to growth factor in the SIS expected to be able to induce tissue repair and stimulate cells to synthesize DNA and proliferate. The influences of concentration of glutaraldehyde (0-0.3%) with a fixed concentration of collagen on the crosslinking rate of collagen gel solutions. In addition, the influences of the addition of antibiotic drus, gentamicin sulfate (GS) on viscosity changes of collagen gel solutions were compared. Collagen films perpared from those gel solutions crosslinked with different concentrations of glutaraldehyde. The diffusion characteristics of antibiotic loaded collagen film were assessed using a flow-through diffusion system. Release amount of GS were analyzed by high performance liquid chromatography (HPLC) and the released GS activity was observed by microbiological assay using Staphylococcus aureus. Acknowledgement: This study was supported by MOICE. |
| 저자 | 황혜진1, 박기숙2, 윤덕일, 강길선, 이종문, 이해방* |
| 소속 | 1전북대, 2*한국화학(연) |
| 키워드 | |
