| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 | 27권 1호, p.288 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Release Profiles of Poorly Water-soluble Drug from Biodegradable Microspheres for The Treatment of Osteoporosis |
| 초록 | The poly(lactide-co-glycolide) (PLGA) due to its controllable biodegradability and excellent biocompatibility is one of the most significant candidates for the study of biodegradable polymeric controlled release. Ipriflavone (IP) stimulates proliferation and differentiation of osteoblast and also enhances calcitonin secretion in the presence of estrogen. IP (poorly water-soluble drug) loaded PLGA microsphere (MS) was prepared by using conventional O/W solvent evaporation method. The different morphology and size distributions can be changed by various factors in the preparation procedure such as molecular weight (8K, 20K, 33K and 90K g/mole) polymer concentration (2.5, 5, 10 and 20%), surfactant types (SDS, PVA, gelatin and Tween 80), initial drug loading (5, 10, 20 and 30%), stirring speed (250, 500 and 1000 rpm) and evaporation temperature (25, 35 and 45℃). In vitro drug release behaviors of IP were determined by high perfomance liqud chromatography (HPLC). These results suggested that IP-loaded PLGA MS may be used as carrier in controlled delivery system for the treatment of osteoporosis. Acknowledgment: This work was supported by KMOHW (Grant No.; HMP-98-G-2-050-A). |
| 저자 | 이진수1, 안태군2, 채강수*3, 강길선4, 정제교**, 이정식**, 이해방*** |
| 소속 | 1전북대, 2*전북대, 3**삼천당제약 중앙(연), 4***한국화학(연) |
| 키워드 | |
