| 초록 |
Hydrogel nanoparticles (nanogels) with various structures have been extensively investigated for therapeutic and diagnostic applications. Recently, our group reported thermosensitive Pluronic nanocapsules shell-crosslinked with heparin or polyethylenimine. In this study, we report a new class of hydrogel nanocapsules encapsulating lipid oils in their hollow capsule structures. These nanocapsules were prepared by dissolving Lipiodol (iodinated lipid oil as CT contrast agent) and Pluronic F127 activated with p-nitrophenyl chloroformate in a methylene chloride phase, and then dispersing in an aqueous phase containing amine-functionalized 6-arm PEG. Shell-crosslinked Pluronic nanocapsules encapsulating Lipiodol were produced and their hydrodynamic diameter was 125 ± 13 nm as determined by dynamic light scattering. 1H-NMR and TEM suggested that Lipiodol was stably encapsulated inside the nanocapsules. We also investigated their application for drug delivery systems and imaging carriers. |
