| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 | 27권 1호, p.289 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Study on Geometric Effects of BCNU-loaded PLGA Wafer on BCNU Release |
| 초록 | Interstitial therapy using biodegradable polymeric device loaded with anticancer agent can deliver the drug to the tumor site in high concentration and hence increase therapeutic efficacy. 1,3-bis(2-chloroethyl)-1-nitrosourea(BCNU) is the most commonly used chemotherapeutic agent for brain tumors. The design of implantable device is regarded as an important factor for the efficient delivery of antitumor agent to a tumor. The purpose of study is to investigate the release pattern of BCNU from various dimension changes of the wafers, such as weight, diameter, thickness, volume, and surface area of wafers. The BCNU-loaded PLGA wafers containing 3.85%, 10%, 20% and 30% of BCNU were prepared in various shape (diameter of 3mm, 5mm and 10mm, thickness of 0.5mm, 1mm and 2mm). In vitro drug release profile of BCNU-loaded PLGA wafers were analyzed by high performance liquid chromatography (HPLC) assay. Moreover, the effects of various geometric factors were confirmed by investigating mass loss, morphology, and molecular weight change of the wafer as well as pH change of release test media. Acknowledgment: This work was supported by KMOCIE |
| 저자 | 이진수1, 안태군2, 강희정, 문대식, 강길선, 성하수*, 이해방* |
| 소속 | 1전북대, 2*한국화학(연) |
| 키워드 | |
