| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 | 27권 1호, p.290 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Bone Formation of Bone Marrow Stromal Osteoprogenitor Cells in Ipriflavone Loaded PLGA Scaffold: Characterization and in vivo Study |
| 초록 | Ipriflavone (IP), a non-hormonal isoflavone derivative, has been shown to interfere with bone remodeling by inhibiting bone resorption and stimulating bone formation. IP-loaded PLGA scaffolds were prepared by novel solvent casting/particle leaching and emulsion freezing drying methods. Characterizations of IP-loaded PLGA scaffolds were analyzed by scanning electron microscope (SEM), mercury porosimetry, X-ray diffractometry (XRD), differential scanning calorimetry (DSC) and so on. Released amount of IP from PLGA scaffold was assayed by high performance liquid chromatograghy (HPLC). IP consistently increased the amount of 45Ca incorporated into the cell layer by bone marrow stromal osteoprogenitor cells (BMSOCs), and stimulated mineralization of BMSOCs assessed by von Kossa staining. We studied the role of BMSOCs reconstituted IP-loaded PLGA scaffolds in athymic nude mice. Differential cell morphology was observed by H&E staining and SEM. Acknowledgement: This study was supported by MOWH(IMT-2000, 01-PJ11-PG9-01NT00-0011). |
| 저자 | 김인영1, 장지욱2, 안태군*3, 이상진**4, 이 봉, 이영무**, 이해방***, 강길선* |
| 소속 | 1부경대, 2*전북대, 3**한양대, 4***한국화학(연) |
| 키워드 | |
