| 초록 |
Synthetic biodegradable materials have been widely used as scaffolds in many tissue engineering applications due to their excellent mechanical properties and easiness for fabrication. However, hydrophobicity and absence of cell anchoring domains have limited interactions between scaffolds and cells, resulting immature tissue regeneration. To overcome these limitations, many researchers have used surface modification techniques including plasma and gamma-ray treatment. Although those methods proved successful in controlling cell responses, they also showed decrease in mechanical properties and molecular weights of synthetic polymer. In this study, we developed gelatin-modified poly(L-lactide-co-ε-caprolactone) (PLCL) nanofibrous substrates using electrospinning and dopamine coating methods. The gelatin-modified PLCL nanofibrous substrates showed better cell compatibilities than those of substrates based on synthetic polymers while maintaining their mechanical properties. |
