| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
19권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Mode of action of synthetic antimicrobial peptides with cell selectivity |
| 초록 |
Emergence of multidrug-resistant bacteria has been raised a limited antibiotic-treatment and demanded a new antibiotic. Antimicrobial peptide(AMP) has different action mechanisms, which are physical perturbation and disruption in microbial membrane, compared with antibiotics. We rationally designed synthetic AMPs by using lysine, isoleucine, typtophan, arginine and glutamic acid. The synthetic peptides showed a potent antibacterial activity for planktonic cells in Pseudomonas aeruginosa and Staphylococcus aureus, drug-resistant bacteria isolated from patients. They are non-toxic against human erythrocytes and mammalian cells. The results are able to provide basic information in designation of synthetic peptides as candidate of AMPs. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded the Ministry of Education, Science and Technology (2013R1A1A4A01010701). |
| 저자 |
박성철, 장미경, 정재은, 허훈, 김영민, 김남홍, 김은지
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| 소속 |
순천대 |
| 키워드 |
Antimicrobial peptide; antibiotic; synthetic AMPs; cell selectivity; multidrug-resistant bacteria
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| E-Mail |
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