| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Collagen/cell incorporating elastic scaffold using pulsatile perfusion bioreactors in the development of a small-diameter vascular graft |
| 초록 |
This study reports on the effects of dynamic culture system and Collagen/ smooth muscle cells (SMCs) mixtures on the cellularity and composition of smooth muscle tissues engineered using biodegradable elastic scaffolds of 4 mm inner diameter and 5 cm length. Rabbit aortic SMCs were infiltrated with collagen solution in tubular PLCL scaffolds under vacuum to form collagenous gel and subjected to pulsatile strain and shear stress by culturing them in pulsatile perfusion bioreactors. The collagen/SMCs incorporating elastic scaffold under pulsatile flow conditions promotes matrix deposition leading to the development of tissue-engineered vascular constructs and induce SMC to have more uniform cell distribution. A collagen/SMCs incorporated scaffolds under pulsatile perfusion conditions can be used as a scaffold for tissue engineering to facilitate small-diameter vascular-tissue formation. |
| 저자 |
박인수1, 김상헌1, 김영하2, 김익환3, 김수현1
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| 소속 |
1한국과학기술(연), 2광주과학기술(연), 3고려대 |
| 키워드 |
Small-diameter vascular grafts; smooth muscle cells; Endothelial cells; collagen gel; biodegradable elastic scaffold; Bioreactor.
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| E-Mail |
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