| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effect of Preparation Conditions on Release Behavior of Raloxifene HCl-Loaded PLGA Microspheres |
| 초록 |
Raloxifene HCl is a second generation selective estrogen receptor modulator that bind to the estrogen receptor and results in estrogen agonist effects on bone. We prepared the raloxifene HCl-laded PLGA microspheres using a oil-in-oil-in-water double emulsion solvent evaporation method for the effective controlled release. raloxifene HCl-loaded PLGA microspheres was characterized on the surface, the cross-section morphology by SEM. The degradation of raloxifene HCl-loaded PLGA microspheres with different PLGA concentrations were characterized by GPC and SEM. In vitro release behavior of raloxifene HCl were analyzed by HPLC over 4 weeks. The morphology and in vitro release profiles of raloxifene HCl-loaded PLGA microspheres were changed by several preparation conditions such as preparation temperatures, PLGA concentrations, solvent volumes, emulsifier concentrations. These results showed that the release behaviors can be effectively controlled by the preparation conditions. |
| 저자 |
엄신, 박종학, 유석철, 김수진, 김용기, 박현진, 이영현, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
raloxifene HCl; O/O/W; PLGA microspheres; GPC; degradation
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| E-Mail |
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