| 초록 |
Even though the steroid drug dexamethasone is an efficacious antiinflammatory drug, it is difficult to formulate in an injectable formulation because of its poorly water solubility. So, polymeric film containing dexamatasone was designed drug delivery system including SIS and sustained release of the drug from the polymeric system. PLGA is used for polymeric film that has been widely used as carriers in controlled release delivery system due to its biodegradability and relatively good biocompatibility. Also, the release behavior of dexamethasone on film controlled by adding the additive such as SIS. In vitro release behavior measured by HPLC and the PLGA molecular weight according to degradation of PLGA analyzed by GPC and pH meter. In this study, the films containing natural materials such as SIS according to content showed zero-order release profile. It was confirmed that the release of dexamethasone form films could be easily controlled by adding SIS. |
