| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Evaluation of In Vitro Release profiles of Valsartan-Loaded PLGA Microspheres by different Preparation Methods |
| 초록 |
Valsartan, a selective angiotensin Ⅱ type 1 receptor(AT1R) antagonist, has high bioavailability. Poly(L-lactide-co-glycolide)(PLGA) has been widely used as a carrier in controlled-release delivery systems because of good biodegradability and relatively high biocompatibility. In this study, We developed PLGA microspheres loaded with valsartan by varying PLGA molecular weight, preparation method and Poly(vinyl alcohol)(PVA) contents. Physicochemical properties and morphology of valsartan-loaded PLGA microspheres were investigated by scanning electron microscope(SEM), fourier-transform infrared spectroscopy(FT-IR), X-ray diffraction(XRD) and differential scanning calorimeter(DSC). The influence of preparation parameters was studied with respect to release of valsartan. These results showed that the release behaviors can be effectively controlled by the preparation conditions |
| 저자 |
엄신, 유석철, 송병주, 김용기, 송이슬, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Valsartan; PLGA microspheres; PVA; controlled-release
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| E-Mail |
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