| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 봄 (04/09 ~ 04/10, 대전컨벤션센터) |
| 권호 |
34권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Evaluation of inflammation response of natural and synthetic biomaterials-based scaffolds. |
| 초록 |
Biomaterial derived from natural and synthetic source can support suitable surface for cell attachment, proliferation, differentiation, and migration. The in vivo inflammation response of biomaterials is very important for practical application in the filed of tissue engineering. In this study, we prepared and characterized PLGA-, SIS- and PLGA/SIS-based scaffolds to compare the host tissue response by immunohistochemical staining with ED1. The scaffold subcutaneously implanted in Fischer rats. Then, we assessed the host tissue response to PLGA-, SIS- and PLGA/SIS-based scaffolds. PLGA-based scaffolds stimulated much higher host tissue responses than SIS-based scaffolds. These findings indicate that it should be possible to improve the biocompatibility and successful engraftment of materials by modifying scaffold to decrease their inflammatory properties. Acknowledgements: This study was supported by a grant from MKE (Grant no. 10030022). |
| 저자 |
강윤미1, 이주영2, 김이슬1, 김재호1, 이해방2, 김문석1
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| 소속 |
1아주대, 2한국화학(연) |
| 키워드 |
Biomaterials; Scaffold; PLGA; Small intestinal submucosa; Inflammation
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| E-Mail |
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