| 학회 | 한국공업화학회 |
| 학술대회 | 2014년 봄 (04/30 ~ 05/02, 제주국제컨벤션센터) |
| 권호 | 18권 1호 |
| 발표분야 | 포스터-정밀화학 |
| 제목 | Synthesis of Aminopeptidase Inhibitor Lapstatin |
| 초록 | Lapstatin is known as a low-molecular-weight aminopeptidase inhibitor and its structure is similar to other aminopeptidase inhibitors such as bestatin and amastatin. While the structure of bestatin was well established and it has been used in the treatment of acute myelocytic leukemia, lapstatin has not been fully utilized as a potential pharmaceuticals probably because of the unidentified stereochemistry of the vicinal amino alcohol at the N-terminal amino acid residue. In our previous study, bestatin and its derivative were readily synthesized by the effective peptide bond formation between α-amino acids and the protected form of threo-β-amino-α-hydroxy acid that was obtained from the stereoselective reaction between the α-amino aldehyde and phenylsulfonylnitromethane. Employing the developed synthetic method, we will present two lapstatin analogues that contain a threo-β-amino-α-hydroxy moiety of lapstatin in order to confirm its stereochemistry. |
| 저자 | 이수범, 서영란, 김영규 |
| 소속 | 서울대 |
| 키워드 | lapstatin; aminopeptidase inhibitor |
