| 초록 |
When using 3D bioprinting to build large constructs, the more hypoxia can be operated on cells in the core of the constructs because of the greater a size of the constructs. Therefore, a space within the structure is used to improve the hypoxia. However, mechanical properties of its construct are weakening due to the empty space. Therefore, we designed a novel concept for assembling the empty spaces of the delicate construct with other precise blocks. In addition, the assembled blocks are given different biodegradability. Consequently, vascularization is promoted into the block with a rapid degradation rate. So, we optimized printing parameters to use alginate correctly. Then, we confirmed sufficient mechanical properties enough to support cells. Moreover, the cell viability was approximately equal to non-printed cells. We are in experiments such as measurement of hypoxia, degradation test and so on. If our concept is confirmed, the assembling blocks would be a promising platform. |
