| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
In vivo bone formation from human embryonic stem cell-derived osteogenic cells and adipose-derived stromal cells in poly(D,L-lactic-co-glycolic acid)/hydroxyapatite composite scaffolds |
| 초록 |
We have previously developed a three-dimensional porous poly(D,L-lactic-co-glycolic acid)/hydroxyapatite composite scaffold as a cell delivery vehicle. In the present study, we explored whether osteogenic cells derived from hESCs (OC-hESCs) and adipose-derived stromal cells (ADSCs) in the scaffold would be capable of regenerating bone tissue in vivo. Both OC-hESCs and ADSCs in the scaffold showed significant bone formation in the subcutaneous sites of immunodeficient mice at four and eight weeks after implantation, more significant in the present of bone morphogenic protein-2. |
| 저자 |
이수홍1, 김병수2, 김시내1, 김상수3, 안성은4, 전오주5, 정형민1
|
| 소속 |
1포천중문의과대, 2한양대, 3Harvard Univ., 4차바이오텍, 5Purdue Univ. |
| 키워드 |
Bioactive scaffold; stem cell; in vivo bone formation
|
| E-Mail |
|
