화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU))
권호 20권 2호
발표분야 콜로이드계면화학_포스터
제목 Novel Amphiphilic PEO-b-PDMS-b-PEO Triblock Copolymers for Controlled Structuring Mixed Polymeric Micelles
초록 Polymeric micelles with inherent and modifiable phases have widened their practical applicability to drug delivery. To further modify the phase property of polymeric micelles, we synthesize two amphiphilic block copolymers, poly(ethylene oxide)-b-poly(ɛ-caprolactone)-b-poly(ethylene oxide) (PEO-b-PCL-b-PEO) with a crystalline hard block and poly(ethylene oxide)-b-polydimethylsiloxane-b-poly(ethylene oxide) (PEO-b-PDMS-b-PEO) with a silicone soft block. Basically, we investigate how mixing these two block copolymers affect their phase miscibility, phase transition, and phase rigidity, by using DSC, XRD, and NMR analyses. From the insight gained from the phase property analyses, we then design new hybrid polymeric micelles by solely changing the mixing ratio. Finally, we experimentally show that our polymeric micelles with controlled phase properties can be used as vehicles for improved transdermal delivery.
저자 서민태, 이진용, 김진웅
소속 한양대
키워드 Triblock copolymer; polymeric micelles
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