초록 |
Polymeric micelles with inherent and modifiable phases have widened their practical applicability to drug delivery. To further modify the phase property of polymeric micelles, we synthesize two amphiphilic block copolymers, poly(ethylene oxide)-b-poly(ɛ-caprolactone)-b-poly(ethylene oxide) (PEO-b-PCL-b-PEO) with a crystalline hard block and poly(ethylene oxide)-b-polydimethylsiloxane-b-poly(ethylene oxide) (PEO-b-PDMS-b-PEO) with a silicone soft block. Basically, we investigate how mixing these two block copolymers affect their phase miscibility, phase transition, and phase rigidity, by using DSC, XRD, and NMR analyses. From the insight gained from the phase property analyses, we then design new hybrid polymeric micelles by solely changing the mixing ratio. Finally, we experimentally show that our polymeric micelles with controlled phase properties can be used as vehicles for improved transdermal delivery. |