| 초록 |
The term “theranostics” was coined to define ongoing efforts in clinics to develop more specific, individualized therapies, and to combine diagnostic and therapeutic capabilities into a single agent. The emergence of nanotechnology has offered an opportunity to draw diagnosis and therapy closer. A novel theranostic system for PDT was developed by designing multifunctional block copolymer-gold nanoparticle (AuNP) conjugates. The FA-PEG-P(Asp-Hyd)-DHLA-modified AuNPs become so stable that their optical property do not change under very harsh conditions. Then, hydrophobic photosensitizers were conjugated to the stable vectors through pH-sensitive linkage. The particle size, size distribution, and morphology of FA-PEG-P(Asp-Hyd)-DHLA-modified AuNPs were determined. In vitro tests using HeLa cells indicated that the AuNPs based nanocarrier had excellent cellular localization and killed HeLa cells effectively compare to free Pheo under laser radiation. |
