| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.90 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Double-layered polymer microspheres for controlled drug delivery |
| 초록 | An important approach of drug delivery systems is to achieve well-controlled drug release rates without initial burst and transmutation. One of the drug delivery systems, biodegradable microspheres can facilitate the modulation of drug release and simple to produce; offer administration through various routes including oral, pulmonary, and parenteral injection. Double-layered microspheres can suppress the intial burst of drugs and achieve the versatile release according to the polymer characteristics. 1 In this study, we fabricated the doubled-layered microspheres composed of PLGA and FITC-dextran by using mechanical stirring and ultrasonic atomizer methods. Microspheres were characterized by SEM, TEM, and fluorescence confocal microscope. We observed double layers in microspheres including the core of FITC-dextran and corona of PLGA. Also, microspheres showed continuous surface and uniform size. Therefore, double-layered microsphere systems fabricated by one step processing can be utilized with great availability in parenteral injection for controlled drug delivery systems. Acknowledgement: This work was supported by KMOST. (a) (b) Figure 1. (a) TEM and (b) confocal image of double-layered microspheres. References 1. M Fialkowski, A Bitner, B A Grzybowski, Self-assembly of polymeric microspheres of complex internal structures, Nature, 4, 93 (2005). |
| 저자 | 강길선1, 김문석2, 서광수2, 육순홍3, 고종태1, 신형식1, 조선행2, 이해방2 |
| 소속 | 1전북대, 2한국화학(연), 3한남대 |
| 키워드 | double-layered microsphere |
