| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Temperature, oxidation, and NIR-responsive liposomes incorporating poly(hydroxyethyl acrylate-co-ethyl vinyl sulfide) and indocyanine green |
| 초록 |
The EPC liposomes were prepared by embellishing the surface of liposomes using poly(hydroxyethyl acrylate-co-ethyl vinyl sulfide) and indocyanine green (ICG). The LCST and surface tension of P(HEA-co-EVS) increased when the EVS was oxidized by H2O2. The liposomes with P(HEA-co-EVS) and ICG were prepared by a film hydration method. The mean diameter of the liposome increased when the EPC to the copolymer mass ratio increased. Liposome released its payload in response to temperature, oxidation, and NIR irradiation. When the temperature was increased above LCST, liposomes would be broken and release their payload. Upon oxidation, the copolymer lost its surface activity causing the liposome to break. Under NIR irradiation, the temperature of the liposome could reach the LCST and the release was higher when the temperature was higher. The ROS-induced oxidation of EVS results in the liposome will be broken and its payload being promoted. |
| 저자 |
KWANJIRA WANGPIMOOL, 손현기, 김진철
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| 소속 |
강원대 |
| 키워드 |
EPC; liposome; hydroxyethyl acrylate; ethyl vinyl sulfide; LCST; photosensitizer; stimuli-responsive release
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| E-Mail |
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