| 초록 |
Integration of viral gene delivery with engineered-biomaterials can be a potential strategy to promote technologies associated with virus-mediated gene delivery for a variety of biomedical applications, including tissue engineering and gene therapy. Viral vectors can be plugged into biomaterials either through encapsulation within the material or immobilization onto a material surface. Subsequently, biomaterial-based gene delivery can increase the vector's residence time within the target site, thereby potentially providing localized delivery, enhancing transduction, patterning gene expression, and extending the duration of gene expression, all of which can be highly critical for maximizing the advantageous properties of viral vectors in biomedical applications. Several powerful tools to create de novo bio-inspired nanoparticles (i.e., gene vectors) formulated with catecholamine family, such as poly(dopamine) or poly(norepinephrine), for enhancing the capabilities of gene delivery will be introduced, and a variety of potential applications using catecholamine-based gene delivery systems will be discussed. |
