화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2012년 봄 (04/25 ~ 04/27, 제주 ICC)
권호 18권 1호, p.475
발표분야 생물화공
제목 Real-Time and Label-Free Detection of Hepatocellular Carcinoma Markers  using Bio-functionalized ZnO/a-C Core-Shell Nanowires
초록 Nanotechnology combined with biotechnology is expected to provide novel paradigm breaking solutions in the area of sensing. Due to the high surface-to-volume ratio of the 1D nanostructure, it has been reported that the detection sensitivity of 1D field effect transistor (FET) biosensors may be increased up to a single-molecular detection level. In this work, we demonstrated real-time and label-free detection of hepatocellular carcinoma markers using effective nanosensor platform. For this work, we introduce two different functionalization schemes to immobilize alpha-feto protein (AFP) antibodies onto the ZnO/a-C (amorphous carbon) core-shell nanowires (NWs) field-effect transistors (FETs) surface for optimizing detection performance: (1) non-covalent binding and (2) covalent binding to the ZnO/a-C core-shell NWs surface. The bio-sensing performance for different type of immobilization methods will be discussed with their sensing mechanisms.
저자 Deepti Sharma, Rizwan Khan, 김진태, 구아영, 송정근, 서지혜, 임연호
소속 전북대
키워드 biotechnology; functionalization; sensing
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