학회 |
한국화학공학회 |
학술대회 |
2012년 봄 (04/25 ~ 04/27, 제주 ICC) |
권호 |
18권 1호, p.475 |
발표분야 |
생물화공 |
제목 |
Real-Time and Label-Free Detection of Hepatocellular Carcinoma Markers using Bio-functionalized ZnO/a-C Core-Shell Nanowires |
초록 |
Nanotechnology combined with biotechnology is expected to provide novel paradigm breaking solutions in the area of sensing. Due to the high surface-to-volume ratio of the 1D nanostructure, it has been reported that the detection sensitivity of 1D field effect transistor (FET) biosensors may be increased up to a single-molecular detection level. In this work, we demonstrated real-time and label-free detection of hepatocellular carcinoma markers using effective nanosensor platform. For this work, we introduce two different functionalization schemes to immobilize alpha-feto protein (AFP) antibodies onto the ZnO/a-C (amorphous carbon) core-shell nanowires (NWs) field-effect transistors (FETs) surface for optimizing detection performance: (1) non-covalent binding and (2) covalent binding to the ZnO/a-C core-shell NWs surface. The bio-sensing performance for different type of immobilization methods will be discussed with their sensing mechanisms. |
저자 |
Deepti Sharma, Rizwan Khan, 김진태, 구아영, 송정근, 서지혜, 임연호
|
소속 |
전북대 |
키워드 |
biotechnology; functionalization; sensing
|
E-Mail |
|
VOD |
VOD 보기 |
원문파일 |
초록 보기 |