| 초록 |
The extracellular matrix (ECM) exhibits heterogeneous sequences or dynamic stretching and shrinking of ligand nanostructures that interact with stem cells to regulate their adhesion and differentiation for tissue regeneration. To mimic and unravel such complex interaction between cells and cell-adhesive Arg-Gly-Asp (RGD) ligand, our group employed nanoporous template-assisted electrodeposition to synthesize such ligand presenting 1-D structures. 1-D nanobarcode, composed of Au and Fe segments in diverse frequency and sequences were developed without modulating the total ligand density where low ligand frequency and terminal ligand sequence facilitated cellular integrin clustering, which enhanced cell adhesion and differentiation. Moreover, ligand-coated magnetic nanocoils were developed. Under external magnetic fields, nanocoils mimicked the ECM dynamicity through cyclic stretching and shrinking, which augmented or suppressed stem cell adhesion and differentiation, respectively. |
