| 초록 |
Interactive surface for Manipulating the cell/tissue is a crucial way to develop long-term implantable materials. Here, we produced particular interfaces with cellular membrane proteins to modulate cell-surface interactions selectively. In the first study, to fabricate a neuro-specific interface, neural-specific cell adhesion molecules (CAM, L1) containing vesicles extracted from differentiated PC-12 cells were used to form a lipid bilayer tethered on the titanium surface. The modified surface was successful in air stability and biofouling standpoints. In addition, the in-vitro study confirmed that modified substrate provides a highly biocompatible surface for neuron cells; in contrast, it limits the astrocyte cell activation and local inflammation. Further, we investigate galectin-1 protein (Gal-1) containing lipid bilayers to protect associated problems with blood-contacting implantable devices |
