| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Secondary Structural Effectto 3D-Chondrocytes-Culture in Thermosensitive PA-PLX-PA Hydrogel |
| 초록 |
Cartilage is one of the expectative targets for tissue engineering, because not only cartilage has limitation for self-repair but also activities of chondrocytes are maintained when they are placed in the proper three-dimensional environment. Chondrocytes are well-known that they would be cultured in 3D condition to enhance the synthesis of extracellular matrix such as GAG and type II collagen, which is an important function of chondrocytes and plays significant roles in regulating the chondrocyte phenotype. Stimuli, such as pH, specific ions, or ionic strenth, responsive hydrogel systems based on beta-sheet showed a number of applications for 3D cell culture. In this study, chondrocytes were cultured in temperature-responsive PA-PLX-PA hydrogels to see the secondary structural effect on chondrocytes. The secondary structures of PA-PLX-PA hydrogels were regulated by varying L-Ala/DL-Ala ratio. |
| 저자 |
최보규1, 이혜선1, 박귀덕1, 정병문2, 한동근1
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| 소속 |
1한국과학기술(연), 2이화여자대 |
| 키워드 |
secondary structure; 3D culture; thermosensitive hydrogel
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| E-Mail |
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