| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effect of PLGA Scaffold Penetrated Demineralized Bone Solution for Chondrgenesis |
| 초록 |
For the effective articular cartilage repair and regeneration, numerous studies have been focused on tissue enfineering approaches motivated by the clinical need. In this study, we developed synthetic/natural hybrid scaffolds with PLGA and DB solution for the application of articular cartilage regeneration. Composite scaffolds of PLGA penetrated DB solution (PLGA-pen-DBP) were manufactured by a solvent casting/salt leaching method soaked in DB solution. The scaffold mechanical strength, histology, immunohistochemistry were performde to elucidate in vitro and in vivo cartilage development and the deposition of cartilage-specific extracellular matrices. we observed better to keep the characteristic of cartilage cell in the PLGA-pen-DBP scaffolds than that PLGA scaffolds. This study suggests that PLGA-pen-DBP scaffold may serve as a potential cell delivery vehicle and a structural basis for in vitro tissue engineered articular cartilage. This research was supported by WCU(R31-20029) |
| 저자 |
서한솔, 유현, 김수진, 임동균, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Chondrocyte; PLGA; Demineralized bone particle (DBP)
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| E-Mail |
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