| 초록 |
Polycyclic compounds possessing an oxindole moiety are important in the search for novel, biologically active agents for the pharmaceutical and agrochemical industries. In addition, dibenzo[b,f]oxepin is an important motif in natural and medicinal compounds. Recently, aristoyagonine occupies a special interest since it is the only example to date of a natural cularine alkaloid incorporating a five-membered lactam. In addition, we have developed two-photon (TP) pH-sensitive probes (BH-2 and BHEt-1). Human colon cancer tissues labeled with BHEt-1 showed excellent results, demonstrating much brighter TPM images and 6-fold larger Pacid values compared to normal tissue. These results suggest the potential utility of BHEt-1 for detecting colon cancer in human tissues using TPM. In this seminar, our efforts towards the syntheses of polycyclic heterocycles and two-photon probes will be presented. |
