| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Characterization and Sustained-Release Formulation of Carvedilol Tablet Prepared by Wet Granulation Method Using Hydroxypropylmethylcellulose |
| 초록 |
Carvedilol, used in the treatment of hypertension and chronic stable angina, has low solubility, bioavailability and high permeability. In this study, we prepared sustained-release matrix tablet by wet granulation method. The wet granulation tablet was formulated using the excipient and HPMC. Scanning electron microscope was used to confirm the morphology of drug, carrier, excipient, and particles prepared by wet granulation method. Differential scanning calorimetry and X-ray diffraction were used to analyze the crystallinity of solid dispersions and wet granulation. Fourier-transform infrared spectroscopy was used to analyze the change in chemical structure of solid dispersions and wet granulation. A release behavior of carvedilol was studied at simulated gastric juice (pH 1.2) in vitro. This research was supported by NRF-2012M3A9C6050204, Bio-industry Technology Development Program (KMFAFF, 112007-05-2-SB010) and the Brain Korea 21 PLUS Project, NRF. |
| 저자 |
박진영, 오승창, 이현구, 김혜민, 김수민, 국현, 김은영, 송정은, 강길선
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| 소속 |
전북대 |
| 키워드 |
release behavior; carvedilol; solid dispersion; dissolution rate
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| E-Mail |
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