| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Effect of Sustained Release Formulations on Loxoprofen Sodium from Kind of Various Polymer and Comparison Dissolution Rate |
| 초록 |
Loxoprofen(LP) is one of the propionic acid classes of nonsteroidal anti-inflammatory drug with analgesic and antipyretic effects. LP is a powerful analgesic and chronic rheumatism, degenerative arthritis. It was prepared for sustained-release of LP by physical mix method. Physical mix tablet was formulated by using the various polymers. Physicochemical variation and shape of LP and polymers were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC) and Fourier-transform infrared spectroscopy (FT-IR). The in vitro test behavior of physical mix was presented in intestinal juice (pH 6.8). This study suggest that added polymers affect the sustained-release formulation system of LP. "This research was supported by NRF-2012M3A9C6050204, Bio-industry Technology Development Program (KMFAFF, 112007-05-2-SB010) and the Brain Korea 21 PLUS Project, NRF." |
| 저자 |
양재원, 박진영, 고현아, 장나금, 김은영, 송정은, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
loxoprofen; polymer; physical mix; sustained-release
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| E-Mail |
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