| 학회 | 한국화학공학회 |
| 학술대회 | 2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 | 12권 2호, p.1389 |
| 발표분야 | 고분자 |
| 제목 | Preparation of magnetic PEI(polyethylenimine)-PHDCA(polyhexadecyl cyanoacrylate) nanoparticle for magnetic drug targeting |
| 초록 | Magnetic polyethylenimine-poly(hexadecyl cyanoacrylate) (PEI-PHDCA) nanoparticles were prepared in a spherical nanoparticle by the emulsion-solvent evaporation method and electric charge interaction with cationic polymer, PEI. The copolymers were characterized by FT-IR spectra, 1H-NMR and gel permeation chromatography (GPC). The morphology and size of magnetic nanoparticles were evaluated by electron microscopes (SEM and TEM). The release profiles of anti-cancer drug in the magnetic nanoparticles were observed for 14 days. In vitro cellular uptake efficiencies were evaluated by epi-fluorescence microscope, fluorescence activated cell sorting (FACS) and magnetic resonance imaging (MRI). The prepared magnetic PEI-PHDCA nanoparticles represented sufficient magnetic properties and cellular uptake for targeted delivery. Acknowledgments : This work was supported by KOSEF through National Core Research Center for Nanomedical Technology (R15-2004-024-00000-0) |
| 저자 | 서성백, 양재문, 허용민, 함승주 |
| 소속 | 연세대 |
| 키워드 | magnetic drug targeting; PEI(polyethylenimine); PHDCA(polyhexadecyl cyanoacrylate) |
| 원문파일 | 초록 보기 |
