| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 22권 2호 |
| 발표분야 | 생물공학_포스터 |
| 제목 | The ethyl acetate fraction of Calendula officinalis L. flowers modulates cellular responses of B16F1 melanoma cells |
| 초록 | Background: Calendula officinalis L. flower, commonly known as marigold, is used to treat various skin diseases, including rashes, burns, cuts, and bruises, since ancient times. However, to our knowledge, the impact of C. officinalis L. on melanoma and its mechanism have not been clarified. Aim of the study: To investigate the chemical, antimelanogenic, and antimigration properties of the ethyl acetate fraction of C. officinalis L. flowers (EFC). Results: EFC markedly decreased α-melanocyte-stimulating hormone-induced melanin production and the migration ability of B16F1 melanoma cells in a concentration-dependent manner. Additionally, EFC significantly inhibited the activity and generation of matrix metalloproteinase 2 by suppressing the mitogen-activated protein kinase signaling pathway. Conclusions: The current study demonstrated that EFC can be used as a natural antimelanogenic and antimigration agent that may aid in the treatment of skin disease. |
| 저자 | 박수남, 현송화, 김아랑, 김지웅 |
| 소속 | 서울과학기술대 |
| 키워드 | Anti-melanogenesis; anti-migration; Calendula officinalis L. flowers; B16F1 melanoma cells |
