| 초록 |
The cryogels, a type of macroporous scaffolds, have a great deal of interest in the diverse biomedical fields due to their interconnected macroporous structure, mechanical stability, and high absorption capacity. Hyperoxia (over 21% pO2) has been demonstrated to promote wound healing, such as proliferation and angiogenesis. Herein, we present a new type of O2-releasing cryogels consisting of thiolated-gelatin and calcium peroxide (CaO2) for facilitating wound healing. The cryogels are fabricated by CaO2-mediated crosslinking reaction followed by freeze-drying. O2 release behavior of cryogels is controlled by varying CaO2 concentrations (8.4 to 15.2 mg/L) and hyperoxic level is sustained for up to 14 hours. Furthermore, we demonstrate that our biocompatible cryogels improve wound closing rate and neovascularization through acute hyperoxic conditions. Taken together, our O2-releasing cryogels have great potential as ideal wound dressing materials for improved wound management. |
