| 초록 |
Gene therapy has been studied as an efficient tool for controlled regeneration or specific inhibition of tissue growth. In order to magnify the efficacy of gene therapy, development of powerful gene delivery carrier is essential issue as well as design of therapeutic gene. In this study, we developed various polymeric gene carriers for delivering therapeutic gene into specific cell or tissues such as tumor tissue and muscle cells. Physicochemical characterization of polymers was evaluated followed by gene transfection assay in vitro. Finally, we investigated the efficacy of gene carriers for delivering therapeutic gene in vivo. |
