| 초록 |
In this study, we present two different hybrid nanoprobes having both magnetic and surface enhanced Raman scattering (SERS) properties for SERS-based detection using the magnetic silver nanoshells (M-AgNSs) and the multi-layered tri-functional magnetic-SERS-fluorescence particles (MF-SERS Particles). We obtained much stronger SERS signal intensity from the aggregated M-AgNSs than from the non-aggregated AgNSs, and the limit of detection for tetramethylthiram disulfide was 10 μM, which corresponds to 3 ppm. Also, the MF-SERS Particles exhibited strong SERS signals from the silver NPs as well as both superparamagnetism and fluorescence. MF–SERS Particles were uptaken by cells, allowing successful separation using an external magnetic field. SERS and fluorescence signals could be detected from the NP-containing cells, and antibody-conjugated MF-SERS Particles selectively targeted cells. Based on these properties, both hybrid nanomaterials were proved to be a useful nanoprobes. |
