| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 |
17권 2호 |
| 발표분야 |
포스터-고분자 |
| 제목 |
Functionalized graphene quantum dots with hyaluronic acid for cellular imaging and drug delivery |
| 초록 |
This work demonstrates the way to target specific delivery of graphene quantum dot (GQD) using hyaluronic acid (HA) (GOD-HA) as a targeting agent. HA was anchored to GQD via dopamine hydrochloride (DN), conjugated to HA. X-ray photo electron spectroscopy (XPS) investigation confirms the anchoring of HA-DN to GQD. Transmission electron microscopy (TEM) observed the particle size near about 20 nm and the fluorescence spectra assured blue color. GQD-HA was applied to CD44 receptor over expressed tumor bearing balb/c mice and the in vivo biodistribution investigation demonstrated strong fluorescence from tumor tissue. In vitro cellular imaging showed the effectiveness of GQD-HA from CD44 over expressed A549 cells. The GQD-HA accumulated hydrophobic drug doxorubicin and released the drug at lower pH. MTT assay strongly supported GQD-HA as biocompatible material. |
| 저자 |
Abdullah-Al-Nahain, 박성영
|
| 소속 |
한국교통대 |
| 키워드 |
Graphene quantum dot; hyaluronic acid; CD44 receptor; in vivo imaging; target delivery
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| E-Mail |
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