| 초록 |
Indomethacin is a non-steroid anti-inflammatory drug used for its antipyretic and analgesic properties. In this study, the indomethacin release behaviors of the poly(ε-caprolactone) (PCL) microcapsules containing Al2O3 were investigated. The Al2O3 was chemically treated in 15 and 30 wt% hydrochloric acid and sodium hydroxide. And the PCL microcapsules containing indomethacin were confirmed using FT-IR. The inclusion of indomethacin into the PCL microcapsules was determined in the presence of indomethacin's specific peak, i.e., υ N-H vibration at 1620 ㎝-1. And the morphologies of the PCL microcapsules were observed with image analyzer and scanning electron microscope (SEM). As a result, the average particle size of the PCL microcapsules was decreased with the increase of the stirring rate. Also, the indomethacin's release behaviors of the PCL microcapsules were obtained with UV/vis spectra. It was found that in the case of using acidic treated Al2O3 the release rate of drug was increased while the adsorption capacity of indomethacin on Al2O3 was decreased due to the decreased specific surface area of Al2O3. |
