| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
대학원생 구두발표(발표10분) |
| 제목 |
Antioxidant and anti-apoptotic effect of vanillin-incorporated copolyoxalate nanoparticles in ischemia/reperfusion injury |
| 초록 |
The major culprit in pathogenesis in ischemia/reperfusion (I/R) injury involves damage from ischemic stroke, inflammation cascade and overproduction of reactive oxygen species (ROS). Particularly, high level of ROS plays a central role in I/R. During I/R, hydrogen peroxide (H2O2) is the most plentiful form of ROS and cause inflammation, apoptosis and following tissue damages. In this study, we developed H2O2-responsive antioxidant polymeric prodrug of vanillin, termed poly(vanillin oxalate) (PVO) which is composed of antioxidant and anti-inflammatory vanillin and H2O2-responsive peroxalate ester linkages covalently in its backbone. Vanillin, released from PVO nanoparticles, exerts antioxidant and anti-apoptotic activities both in a cell culture model and an animal model of hepatic I/R. Therefore, we anticipate that PVO nanoparticles have tremendous potential as therapeutic and protective agents for I/R injury and H2O2-associated diseases. |
| 저자 |
박민형, 강창선, 양원석, 유우영, 강길선, 이동원
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| 소속 |
전북대 |
| 키워드 |
antioxidant; reactive oxygen species; ischemia/reperfusion injury
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| E-Mail |
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