| 학회 | 한국공업화학회 |
| 학술대회 | 2014년 봄 (04/30 ~ 05/02, 제주국제컨벤션센터) |
| 권호 | 18권 1호 |
| 발표분야 | 포스터-정밀화학 |
| 제목 | Total synthesis of Pareirubrine B |
| 초록 | Pareirubrine B, a member of a family of naturally occurring tropoloisoquinoline alkaloids, is isolated from the roots of Cissampelos pareira(Menuspermaceae). It is reported to display significant antileukemic activity (IC50 = 0.55 µM against the leukemia P388 cell line). In spite of its potent biological activity and even attractive structure from a synthetic point of view, total synthesis of pareirubrine B has not been reported yet. Herein, we will report the first total synthesis of pareirubrine B using our synthetic strategy developed for pareitropone,1 another potent family member of tropoloisoquinoline alkaloids, employing the radical anionic coupling to construct the annulated tropolone structure. 1) Y. G. Kim et al., Org. Lett., 2010, 12, 3954. |
| 저자 | 신나라, 김현정, 홍수림, 김영규 |
| 소속 | 서울대 |
| 키워드 | Tropoloisoquinoline alkaloids; Total synthesis; Antileukemic activity |
