| 초록 |
Graphene oxide (GO) have attracted much attentions in optical sensing as luminescent nanomaterial to be readily used after functionalization and modification of platform structure. Previously, we reported GO/peptide-Quencher hybrid using inherent fluorescence of GO for detection of proteases, and GO/peptide-Quencher hybrid successfully monitored proteases. However, this system was suffered from the complexity of its synthesis due to the integration of quencher. Here, we present a new GO-peptide hybrids sensor for the detection of matrix metalloproteinase-2 (MMP-2) using self-quenching strategy through aggregation induced by disulfide bond formation between GO-peptide hybrids. As expected, the ‘turn-on’ response of GO-peptide sensors was increased depending on the concentration of MMP-2. The GO-peptide self-quenching system proves to be facile, low-cost, stable and biocompatible biosensor to detect MMP-2. |
