| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
19권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Biomimetic chitosan–polyvinyl pyrrolidone films for medical application |
| 초록 |
Lotus-leaf-like structured chitosan–PVP films were prepared using a solution casting method with dodecyltrichloro-immobilized SiO2 nanoparticles. We evaluated whether the lotus-leaf-like structured chitosan–PVP films could be applied as postsurgical anti-adhesion barriers. A recovery test using a tensile strength testing machine and mea-surement of crystallinity using X-ray diffraction indicated that films with 75% PVP were the optimalcomposition of the chitosan–PVP films. Also, dodecyltrichloro-immobilized SiO2nanoparticles were syn-thesized and sprayed on the film after pretreatment with the instant bio-glue. Analysis of cell adhesion,proliferation, and anti-thrombus efficiency were performed via a WST assay, field emission scanningelectron microscopy, and hemacytometry. The contact angle with the lotus-leaf-like surface was ofapproximately 150◦. Furthermore, the l-chitosan–PVP film yielded a lower cell and platelet adhesion rate(around less than 4%) than that yielded by the untreated film. |
| 저자 |
이은경1, 이우걸2, 정은진2, 이수희2, 김지혜2, 김주승2, Le Thi Kim Tram2, 임진익2
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| 소속 |
1(주)미래아이앤지, 2단국대 |
| 키워드 |
Anti-adhesion barrier; Anti-thrombotic surface; Lotus-leaf-like structure
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| E-Mail |
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