| 초록 |
Fragmented nucleic acids from apoptotic cells can activate immune cells. It is important to developing materials that can inhibit the proinflammatory effects of any nucleic acid. Therefore, we fabricated super cationic nanofibrous mesh as a molecular scavengers for free nucleic acid. Poly(-caproloactone)-branched polyethyleneimine (PCL-BPEI) block copolymer was synthesized and the surface exposed amine groups of PCL-BPEI nanofibrous mesh were replaced to tri-methyl group. We speculated that the tri-methyl group of nanofibrous mesh can significantly increase the cationic charges on the nanofiber and enhanced electrostatic interactions toward anionic molecules. Various amount of DNA was added to the nanofibrous mesh to confirm the scavenging effect for nucleic acids. In conclusion, the charge density on the nanofibrous mesh could be controlled by tri-methylation and this super cationic nanofibrous mesh can maximize the binding efficiency of nucleic acids. |
