| 초록 |
Photodynamic therapy (PDT) has been receiving attention in the field of cancer therapy. In particular, PDT induces the release of ROS after laser irradiation, thereby attaining targeted therapy. Accordingly, PS with various abilities have been developed to enhance the effectiveness of phototherapy through PDT, one of which is to target the mitochondria of cancer cells. Their transmembrane potential is higher than that in normal cells, thus it can be used to target specific mitochondria. Furthermore, PDT can increase apoptosis by directly damaging the mitochondria. Dyes in the NIR region have a merit in biomedical applications, but compared to existing dyes in the visible region their singlet oxygen yield is low. Therefore, we hypothesized that by developing a chemically modified PDT agent that targets the mitochondria of cancer cells to increase ROS production, an effective cancer phototherapy system can be established. |
