| 초록 |
Conductive hydrogels have been promising for medical applications such as implantable bioelectronics. Recently, there is importance of the conductive hydrogels for monitoring biological signals after implantation. However, existing conductive materials which are rigid and insoluble have challenges to achieve optimal stretchability, self-healing and electrophysiological properties matching to biological tissues. Herein, we propose conductive hydrogel consisting of ‘boronic acid modified alginate’ and ‘oligomerized epigallocatechin gallate’ via dynamic covalent bonds between boronic acid and cis-diol of gallol groups. The reversible crosslinking allowed stretchability up to 500% and self-healing property. In addition, exposure to salt solution increased ionic conductivity. Interestingly, the hydrogel could be electrophysiological bridge in ex vivo muscle defect model. This strategy to design biocompatible and conductive hydrogels would be useful for engineering implantable materials. |
