| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Oxygen Carrier-Loaded Hollow Microparticles for Prolonged Cell Survival and Effective Bone Regeneration |
| 초록 |
The tissue-engineering technique for functional tissue/organ replacement has been extensively studied. The 3D porous scaffolds which guide growth and differentiation are widely utilized as a pivotal factor for sufficient tissue/organ regeneration. However, cell necrosis in the central region of 3D cell scaffold, due to the insufficient oxygen diffusion is considered as critical huddle for the formation of 3D tissues/organs. In this study, we developed a perfluorooctane-loaded hollow microparticles (PFO-HP) as an oxygen carrier which can allow sustained oxygen release for sufficient period, and thus provide appropriate environment for cell survival even hypoxia. Cell (human periosteum-derived cells) proliferation (in hypoxia) and differentiation (after 10 days cell culture in hypoxia) in the PFO-HP were investigated. In vivo animal study to evaluate the bone regeneration behavior of hPDCs-loaded PFO-HP was also conducted using a miniature pig model (mandibular defect). |
| 저자 |
김소영1, 김호용1, 변준호2, 이진호3, 오세행1
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| 소속 |
1단국대, 2경상대, 3한남대 |
| 키워드 |
oxygen carrier; perfluorooctane; cell survival; osteogenic differentiation
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| E-Mail |
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