| 초록 |
Poly(DL-lactide-co-glycolide) (PLGA) has two types ; one is PLGA (RG 502) and the other PLGA (RG 502H). The surfactant-free nanoparticles of PLGA were prepared by dialysis method without surfactant and physicochemical properties such as particle size were investigated against used intial solvent. Used intial solvents are dimethylacetamide (DMAc), dimethylformamide (DMF), dimethylsulfoxide (DMSO), and acetone, respectively. PLGA (RG 502) nanoparticles had spherical shapes from the results of scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observations. And it was investigated on the surface of nanoparticles through the analysis of X-ray power diffraction. Also, PLGA (RG 502H) nanoparticles have been observed SEM, TEM, and X-ray powder diffraction.
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