| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 |
22권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Bioabsorbable stent with core-shell nanoparticles for improving x-ray absorption and inflammation inhibition |
| 초록 |
Recently, a new-generation stent made of a biodegradable polymer has been actively researched and developed. The biodegradable polymers such as poly-L-lactic acid (PLLA) is completely decomposed in the body within a few years. Bioabsorbable stents have been developed using biodegradable polymers that completely disappear in the body to overcome the disadvantages of metal-based stents which induce late thrombosis and restenosis. However, since polymeric materials composed of atoms with low atomic numbers do not absorb X-rays as much as sufficient for X-ray imaging, biodegradable polymer stents cannot be imaged in X-ray based imaging devices. In this study, we developed a radiopaque bioabsorbable stent with anti-inflammatory effect by using core-shell nanoparticles. To synthesize the radio-opaque nanoparticle, gold nanoparticles were encapsulated with magnesium oxide to add the ability to neutralize the acidic environment induced by the degradation products of biodegradable polymers. |
| 저자 |
김대환1, 박우람2, 이규백3, 한동근2
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| 소속 |
1CHA Univ. / Korea Univ., 2CHA Univ., 3Korea Univ. |
| 키워드 |
Bioabsorbable stent; nanoparticle; contrast agent
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| E-Mail |
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