| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II (영어발표) |
| 제목 |
Stimuli-responsive PLA-based Nanomaterials for Biomedical Applications |
| 초록 |
Polylactide (PLA)-based nanomaterials have been extensively explored in biomedical applications due to their biocompatibility and biodegradability. However, PLA has two main limitations: hydrophobicity and slow degradation rate. My research focuses on the exploration of potential approaches to circumvent these challenges by synthesis of PLA-based amphiphilic block copolymers (ABPs) with stimuli-responsive degradation (SRD) and these ABPs are used to fabricate novel PLA-based nanomaterials. They were further used to fabricate various nanomaterials including micellar drug carriers; polyplexes; and nanofibers. Under a reductive environment, these novel PLA-based nanomaterials are rapidly degraded upon the cleavage of disulfides, leading to controlled release of drugs and genes, as well as change of surface properties. These results suggest the disulfide-labeled PLA-based nanomaterials offer great potential and versatility in biomedical applications. |
| 저자 |
고나래 |
| 소속 |
Univ. of Ulsan College of Medicine |
| 키워드 |
polylactide; amphiphilic block copolymers; stimuli-responsive degradation; drug delivery system; nanomaterials
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| E-Mail |
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