| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
Functional Colloids for Dermatology |
| 제목 |
Formation of Hierarchical Structures with Functional Colloids and Lipo-Polymersomes |
| 초록 |
In this study we investigate the formation and control of compositional heterogeneities in hybrid lipo-polymersomes (HLPs) created by mixing di-block copolymer with common natural lipids. Mixing and de-mixing of lipid-rich domains from the polymer-rich matrix of hybrid vesicles is controlled via thermally driven phase separation and by the inclusion of cholesterol. Domain size and morphology can be controlled by cooling rate and lipid composition, respectively. We also focus on heterogeneous adhesion between two different sized vesicles (Large/Giant Unilamellar Vesicles) or particles functionalized with two different site-specific adhesive functionalities: sequence specific DNA hybridization and effectively irreversible ligand-recepter (biotin-avidin) interactions. This study presents a protocol to constitute recognition based programming hierarchical structures of nano-sized vesicles or particles to micron-sized one conjoining phospholipid and di-block copolymer vesicles. |
| 저자 |
남진 |
| 소속 |
아모레퍼시픽 기술(연) |
| 키워드 |
liposome; polymersome
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| E-Mail |
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