| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Biodegradable Polymersome as Artificial Cell-Like Structure Encapsulated Bcl-xL siRNA and Doxorubicin for Synergistic Anticancer Effect |
| 초록 |
Combined cancer treatment via co-delivery of siRNAs and an anticancer drug can be a promising strategy due to the synergistic effect of simultaneously minimizing gene/drug administration. In this study, Bcl-xL siRNA and doxorubicin (DOX) were encapsulated into designed methoxy-poly(ethylene glycol)-b-poly(D,L-lactic acid) (mPEG-b-PLA) block copolymer polymersomes (PSomes). PSomes prepared by the thin film hydration method consisted of a hydrophilic core and hydrophobic shell to load Bcl-xL siRNA and DOX respectively and provided significant storage capacity. A study of the cytotoxicity of Bcl-xL siRNA and DOX co-encapsulated PSomes (CPSomes) showed that more inhibit proliferation of MKN-45 and MKN-28 human gastric cancer cell lines than only gene- and drug- loaded ones. Consequently, these results demonstrated that co-delivery of gene and drug using PSomes resulted in a synergistic efficacy and indicated the potential of PSomes as efficient nanocarriers for combined cancer therapy. |
| 저자 |
김현욱, 김은정, 안용희, 최지혜, 장은지, 강병훈, 서진석, 허용민, 함승주
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| 소속 |
연세대 |
| 키워드 |
bcl-xL-specific siRNA; biodegradable; doxorubicin; drug delivery systems; polymersomes
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| E-Mail |
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