| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Rational Design of Nano-Thin and Porous Membranes for Stem Cell-Derived Cardiac Sheets through Co-Culture and Transfer-Printing |
| 초록 |
For the best performance of membrane-based co-culture of stem cells to promote the differentiation of the stem cells into a desired cell type, we developed nano-thin and highly porous (NTHP) membranes that allow effective interactions between co-cultured cells. The ultra-thin and nanoporous structure of the NHTP membranes was realized by the vapor-induced phase separation (VIPS) mechanism during spin-coating process. By using this simple processing method, the pore-size of the NTHP membranes can be finely tuned by varying processing parameters. Furthermore, we were able to conformally graft thermoresponsive polymer brushes onto the NTHP membrane via the initiated chemical vapor deposition (iCVD) process to prepare ECM-preserved, transfer-printable cardiac sheets after co-culture. The membranes developed in the present study are expected to facilitate the effective co-culture for differentiating stem cells and producing various types of cell sheets applicable in regenerative medicine. |
| 저자 |
차국헌1, 김병수1, 임성갑2, 박주연1, 유승정2, 한진1, 장영선1, 유승미1, 류진1
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| 소속 |
1서울대, 2한국과학기술원 |
| 키워드 |
mesenchymal stem cells; membrane; co-culture; cardiac differentiation
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| E-Mail |
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